Table 6 Results of LOPO cross validation of our method with respect to 14 RBPs
From: Predicting protein-binding regions in RNA using nucleotide profiles and compositions
| Â | TP | TN | FP | FN | Sensitivity | Specificity | Accuracy | PPV | NPV | MCC |
|---|---|---|---|---|---|---|---|---|---|---|
AGO1 | 37 | 50 | 3 | 18 | 67.27% | 94.34% | 80.56% | 92.50% | 73.53% | 0.638 |
AGO2 | 39 | 49 | 2 | 18 | 68.42% | 96.08% | 81.48% | 95.12% | 73.13% | 0.664 |
EWSR1 | 200 | 198 | 14 | 14 | 93.46% | 93.40% | 93.43% | 93.46% | 93.40% | 0.869 |
FUS | 468 | 534 | 46 | 19 | 96.10% | 92.07% | 93.91% | 91.05% | 96.56% | 0.879 |
FXR1 | 3 | 7 | 0 | 1 | 75.00% | 100.00% | 90.91% | 100.00% | 87.50% | 0.810 |
FXR2 | 25 | 33 | 1 | 11 | 69.44% | 97.06% | 82.86% | 96.15% | 75.00% | 0.688 |
IGF2BP2 | 57 | 55 | 7 | 15 | 79.17% | 88.71% | 83.58% | 89.06% | 78.57% | 0.678 |
LIN28A | 221 | 263 | 25 | 57 | 79.50% | 91.32% | 85.51% | 89.84% | 82.19% | 0.714 |
LIN28B | 2214 | 2343 | 329 | 227 | 90.70% | 87.69% | 89.13% | 87.06% | 91.17% | 0.783 |
QKI | 3 | 5 | 0 | 1 | 75.00% | 100.00% | 88.89% | 100.00% | 83.33% | 0.791 |
TAF15 | 11 | 16 | 1 | 2 | 84.62% | 94.12% | 90.00% | 91.67% | 88.89% | 0.796 |
TARDBP | 39 | 159 | 14 | 149 | 20.74% | 91.91% | 54.85% | 73.58% | 51.62% | 0.179 |
YTHDF2 | 35 | 39 | 5 | 6 | 85.37% | 88.64% | 87.06% | 87.50% | 86.67% | 0.741 |
ZC3H7B | 388 | 438 | 43 | 94 | 80.50% | 91.06% | 85.77% | 90.02% | 82.33% | 0.720 |
Total | 3,740 | 4,189 | 490 | 632 | Â | Â | Â | Â | Â | Â |
Weighted average | Â | Â | Â | Â | 85.54% | 89.53% | 87.60% | 88.42% | 86.89% | 0.752 |