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Fig. 2 | BMC Systems Biology

Fig. 2

From: PINTnet: construction of condition-specific pathway interaction network by computing shortest paths on weighted PPI

Fig. 2

Constructing a shortest path-weaved subnetwork. g indicates genes. c i indicates the closeness centrality of a gene of subnetwork i. Overlapping genes are colored in blue, the direct neighbors of the overlapping genes belonging to pathway A are colored in green and the direct neighbor genes belonging to pathway B are colored in orange. The others are colored in gray. a A subnetwork of pathway A and pathway B b Closeness centrality is calculated for every gene in the subnetwork. The node size represents the closeness centrality of the node. c The genes that are not direct neighbors to overlapping genes are pruned. d Shortest paths are computed. e The shortest paths are weaved to construct a shortest path-weaved subnetwork

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