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Fig. 5 | BMC Systems Biology

Fig. 5

From: PINTnet: construction of condition-specific pathway interaction network by computing shortest paths on weighted PPI

Fig. 5

A pathway interaction network of bone metastasis from breast cancer. Sixty-six pathways are connected by 122 edges in this network. The original paper reported Jak-STAT signaling pathway (hsa04630), cytokine-cytokine receptor interaction (hsa04060), Hippo signaling pathway (hsa04390) and bone metastasis were upregulated in the control compared to ABL1/ABL2 knockdown mice. We found multiple paths from Ras signaling pathway (hsa04014), ABL kinases belong to, to osteoclast differentiation (hsa04380) through MAPK signaling pathway (hsa04010), Wnt signaling pathway (hsa04390), TGF- β signaling pathway (hsa04350), PI3K-Akt signaling pathway (hsa04151), Hippo signaling pathway (hsa04390) and proteoglycans in cancer (hsa05205). We found the evidences in literature that these pathways are related to bone metastasis from breast cancer. These pathways and the edges between the pathways are colored in red and the width of edges are set according to the activation score

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