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Table 3 Gene ontology results of 3 modules on Pareto front detected by the proposed algorithm in network 1

From: Prior knowledge guided active modules identification: an integrated multi-objective approach

Module

Size

S A

R A

Typical GO terms

p-value

1

65

393.41

9

galactose catabolic process via UDP-galactose

5.15×10−03

    

negative regulation of mating-type specific transcription from RNA polymerase II promoter

1.21×10−02

    

glycolytic fermentation to ethanol

4.05×10−02

    

pheromone-dependent signal transduction involved in conjugation with cellular fusion

6.39×10−03

    

cellular carbohydrate metabolic process

4.16×10−02

2

92

268.96

19

negative regulation of mating-type specific transcription from RNA polymerase II promoter

4.67×10−04

    

galactose catabolic process via UDP-galactose

1.63×10−02

    

regulation of transcription during mitosis

7.19×10−03

    

gluconeogenesis

1.84×10−04

    

glycolytic process

2.87×10−02

    

pyruvate metabolic process

4.20×10−02

    

response to pheromone involved in conjugation with cellular fusion

3.93×10−06

3

126

181.3

25

negative regulation of mating-type specific transcription from RNA polymerase II promoter

1.80×10−03

    

galactose catabolic process via UDP-galactose

4.48×10−02

    

C-terminal protein lipidation

1.62×10−02

    

gluconeogenesis

1.36×10−03

    

ADP metabolic process

2.47×10−04

    

pyruvate metabolic process

7.73×10−05

    

response to pheromone involved in conjugation with cellular fusion

1.47×10−02

    

ribonucleoprotein complex assembly

5.31×10−03

  1. Module 1 is the extreme point with maximized active score S A . Module 2 is a balanced solution between S A and R A . Module 3 is the other extreme point with maximized pathway coverage score R A