Table 3 Gene ontology results of 3 modules on Pareto front detected by the proposed algorithm in network 1
From: Prior knowledge guided active modules identification: an integrated multi-objective approach
| Module | Size | S A | R A | Typical GO terms | p-value |
|---|---|---|---|---|---|
| 1 | 65 | 393.41 | 9 | galactose catabolic process via UDP-galactose | 5.15×10−03 |
| negative regulation of mating-type specific transcription from RNA polymerase II promoter | 1.21×10−02 | ||||
| glycolytic fermentation to ethanol | 4.05×10−02 | ||||
| pheromone-dependent signal transduction involved in conjugation with cellular fusion | 6.39×10−03 | ||||
| cellular carbohydrate metabolic process | 4.16×10−02 | ||||
| 2 | 92 | 268.96 | 19 | negative regulation of mating-type specific transcription from RNA polymerase II promoter | 4.67×10−04 |
| galactose catabolic process via UDP-galactose | 1.63×10−02 | ||||
| regulation of transcription during mitosis | 7.19×10−03 | ||||
| gluconeogenesis | 1.84×10−04 | ||||
| glycolytic process | 2.87×10−02 | ||||
| pyruvate metabolic process | 4.20×10−02 | ||||
| response to pheromone involved in conjugation with cellular fusion | 3.93×10−06 | ||||
| 3 | 126 | 181.3 | 25 | negative regulation of mating-type specific transcription from RNA polymerase II promoter | 1.80×10−03 |
| galactose catabolic process via UDP-galactose | 4.48×10−02 | ||||
| C-terminal protein lipidation | 1.62×10−02 | ||||
| gluconeogenesis | 1.36×10−03 | ||||
| ADP metabolic process | 2.47×10−04 | ||||
| pyruvate metabolic process | 7.73×10−05 | ||||
| response to pheromone involved in conjugation with cellular fusion | 1.47×10−02 | ||||
| ribonucleoprotein complex assembly | 5.31×10−03 |