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Fig. 4 | BMC Systems Biology

Fig. 4

From: Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines

Fig. 4

Calibrated model using a Bayesian approach. Dynamic responses of pRaf, ppMEK and ppERK after stimulation with EGF a and NGF b. Shown are the values acquired from flow cytometry experiments (Fig. 1) in comparison to the respective PPDs predicted by the model. Data have been normalized to t=5 min. c Comparison of data for the global response coefficients (GRC) extracted from the siRNA perturbation experiments (Fig. 2), and respective simulated distributions, here for clarity represented with the first and second moment. Data are taken from [12]

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