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Fig. 6 | BMC Systems Biology

Fig. 6

From: Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines

Fig. 6

Steady state analysis using the circuit-breaking algorithm. The CBA is used for an efficient calculation of the steady states of the system for the MCMC parameter samples and subsequent automatic classification into mono- and bistable systems (a-c). d Result of this classification analysis. Depicted is also the distribution of the second stable steady state \(\bar z_{3}\ne 0\) in case of a bistable system, which corresponds to the concentration of active ERK normalized to t=5 min (see Additional file 2)

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