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Fig. 7 | BMC Systems Biology

Fig. 7

From: Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines

Fig. 7

Simulation-based analysis of the long-term behavior of the cell population. a Trajectories are automatically classified into bistable, quasi-bistable and monostable systems, as described in the text. For stimulation with NGF in the control experiment 90% show a quasi-bistable behavior, while only 10% are really bistable. b Distribution of the second stable steady state distinct from zero of the bistable trajectories. c For the choice of threshold parameters that were used for the classification scheme we evaluated the 0% and 100% percentiles of ERK trajectories in the simulation of the NGF control experiment

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