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Table 1 Most significant pathways and processes in the GRN (Fig. 1 a) shown by a network–based gene set enrichment analysis

From: Gene regulatory network underlying the immortalization of epithelial cells

KEGG – Pathway or Process (carcinomas marked in italics) Functional association (XD–score) q-value Overlap/Size
Bladder cancer 1.06805 0 11/38
Chronic myeloid leukemia 0.66539 0 13/69
p53 signaling pathway 0.68435 0 12/62
Pancreatic cancer 0.53872 0 11/70
Glioma 0.57682 0 10/60
Non–small cell lung cancer 0.61604 0 9/51
Melanoma 0.55531 0 10/62
Small cell lung cancer 0.39796 0 10/82
Prostate cancer 0.43396 0 11/84
Cell cycle 0.44349 0 16/120
Cytosolic DNA–sensing pathway 0.48155 0.00001 6/40
Thyroid cancer 0.39015 0.00564 3/25
Endometrial cancer 0.31015 0.00018 5/50
GO Biological Process    
Replicative senescence 3.138 0 8/10
Cellular senescence 0.738 0.01815 2/10
Cell aging 0.438 0.00461 3/24
Positive regulation of epithelial to mesenchymal transition 0.438 0.03501 2/16
Determination of adult lifespan 0.33328 0.40382 1/10