Table 1 Most significant pathways and processes in the GRN (Fig. 1 a) shown by a network–based gene set enrichment analysis
From: Gene regulatory network underlying the immortalization of epithelial cells
KEGG – Pathway or Process (carcinomas marked in italics) | Functional association (XD–score) | q-value | Overlap/Size |
|---|---|---|---|
Bladder cancer | 1.06805 | 0 | 11/38 |
Chronic myeloid leukemia | 0.66539 | 0 | 13/69 |
p53 signaling pathway | 0.68435 | 0 | 12/62 |
Pancreatic cancer | 0.53872 | 0 | 11/70 |
Glioma | 0.57682 | 0 | 10/60 |
Non–small cell lung cancer | 0.61604 | 0 | 9/51 |
Melanoma | 0.55531 | 0 | 10/62 |
Small cell lung cancer | 0.39796 | 0 | 10/82 |
Prostate cancer | 0.43396 | 0 | 11/84 |
Cell cycle | 0.44349 | 0 | 16/120 |
Cytosolic DNA–sensing pathway | 0.48155 | 0.00001 | 6/40 |
Thyroid cancer | 0.39015 | 0.00564 | 3/25 |
Endometrial cancer | 0.31015 | 0.00018 | 5/50 |
GO Biological Process | Â | Â | Â |
Replicative senescence | 3.138 | 0 | 8/10 |
Cellular senescence | 0.738 | 0.01815 | 2/10 |
Cell aging | 0.438 | 0.00461 | 3/24 |
Positive regulation of epithelial to mesenchymal transition | 0.438 | 0.03501 | 2/16 |
Determination of adult lifespan | 0.33328 | 0.40382 | 1/10 |