Fig. 2

Four metastable clusters, or network “macrostates”, identified for the MISA network by the Markov State Model approach. (Rate parameters same as Fig. 1) a Macrostate centers located by their respective 50% probability contours (ellipsoids), corresponding to visible peaks in the probability landscape. The locations of the ellipsoids are determined by grouping the most-probable, rank-ordered microstates within each macrostate, until the total probability of grouped microstates is 50% of the total macrostate probability. b Schematics of the most probable gene promoter configuration for each metastable cluster