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Fig. 7 | BMC Systems Biology

Fig. 7

From: Rewiring of the inferred protein interactome during blood development studied with the tool PPICompare

Fig. 7

HSC →MPP rewiring events in Cytoscape. We visualized the differential network of the transition HSC →MPP in Cytoscape 3.3 [31] using the default output files of PPICompare. The nodes depict all proteins affected by significant rewiring events. All proteins (internally Uniprot accessions) are displayed with their associated gene’s name. Proteins that belong to the “small set of likely changes” are colored blue. The size of nodes increases with their importance score as described in the “Methods” section. Furthermore, protein nodes with a rectangular shape were solely deregulated by AS (here: FOSL1). Green edges depict emerging interactions and red edges the vanishing ones. The edge thickness indicates how often the event was observed throughout the pairwise comparisons (here either in 15 or in 18 of 18 comparisons). Here, only the largest connected component of the differential network is shown (lower left)

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