Table 1 Reaction rates considered in the model

f _IFN

\(V_{IFN}\left (\frac {IFN^{n}}{k^{n}_{IFN}+IFN^{n}}\right)\)

f _dIFN

k _dIFN ·I F N

f _{I S G F3}

k _{I S G F3}·I F N

f _{d I S G F3}

k _{d I S G F3}·I S G F3

\(f_{P_{a}}\)

\(k_{on}\left (\frac {ISGF3 \cdot IRF7dimer}{k_{aI3} \cdot k_{aI7} + k_{aI3} \cdot ISGF3 + k_{aI7}\cdot IRF7dimer + ISGF3 \cdot IRF7dimer}\right)(1-P_{a})\)

\(f_{dP_{a}}\)

k _off ·P _a

\(f_{mRNA_{A}}\)

k _Active ·P _a

\(f_{mRNA_{B}}\)

k _Basal (1−P _a )

f _dmRNA

k _dmRNA ·m R N A

f _{I R F7}

k _{I R F7}·m R N A

f _{I R F7p h o s p}

k _{d I R F7}·I R F7

f _{I R F7d i m e r}

k _{I R F7d i m e r} ·I R F7p h o s p·I R F7p h o s p

f _{d I R F7d i m e r}

k _{d I R F7d i m e r} ·I R F7d i m e r