Fig. 5

Relaxation dynamics of the PBTK models. a The kernel density plot of the relaxation half-lives of the whole-body chemical concentrations in the 7C (black), 6C (red), and 1C (blue) models. The sample populations of half-lives were taken from n = 10³ simulations varying the body parameters in a fashion similar to that described for Fig. 4. The differences in the means from the 7C vs. 1C and 6C vs. 1C are statistically significant (p < 0.01, Student’s t-test). Note that the relaxation half-lives are plotted on a log₁₀ scale. b The kernel density plot of the relaxation half-lives of the whole body (black) and tissue-specific chemical concentrations for the brain (red), gonads (blue), poorly perfused tissue (green), richly perfused tissue (orange), liver (purple), arterial blood (magenta), and venous blood (cyan). Note that the relaxation half-lives are plotted on a log₁₀ scale. c The kernel density plot of the relaxation half-lives of the whole body (black) and tissue-specific chemical concentrations for the brain (red), gonads (blue), liver (purple), “other” tissues (green), arterial blood (magenta), and venous blood (cyan). Note that the relaxation half-lives are plotted on a log₁₀ scale