Fig. 6

Influence of model design on reverse toxicokinetic predictions. a The log₁₀ of the ratio of the predicted environmental concentrations of the 6C rTK model vs. the 1C model as a function of the log₁₀ metabolism/excretion rate (k_met) and the log₁₀ octanol-water ratio (K_ow). Note that for the observed range of values for k_met and K_ow we see no points in which the 6C model overestimates the 1C model (log₁₀ ratio of concentrations > 0). b The log₁₀ of the ratio of the predicted environmental concentrations of the 7C rTK model vs. the 1C model as a function of the log₁₀ metabolism rate (k_met) and the log₁₀ octanol-water ratio (K_ow). Note that the 7C model only overestimates the 1C model (log₁₀ ratio of concentrations > 0) at high values of k_met and K_ow