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Table 8 Parameter values achieved in the calibration to check the robustness of the fed-batch model. The confidence interval on the time where the consumption of secondary metabolites started TCONS, could not be determined due to the stiffness of the solution caused by a sudden consumption of arabitol and ethanol

From: Dynamic genome-scale metabolic modeling of the yeast Pichia pastoris

Parameter Value Units
v MAX 2.09 ± 0.46 mmol/gDCW · h
K S 5.55 · 10−2 ± 0.0000004 · 10−2 g/L
v Pyr,B 0 mmol/gDCW · h
v Arab,B 0.42 ± 0.17 mmol/gDCW · h
v Cit,B 0.04 ± 0.00 mmol/gDCW · h
v Pyr,FB 0 mmol/gDCW · h
α B 2.6 · 10−4 ± 0.4 · 10−4 [−]
α FB 2.455 · 10−5 ± 0.003 · 10−5 [−]
m ATP 7.0 ± 1.4 mmol/gDCW · h
T Cons 25.73 H