Fig. 5
From: Predicting network modules of cell cycle regulators using relative protein abundance statistics
Flowchart of the parameter space exploration approach with the top-performing Scheme 8. Prediction matrix P is generated by simulating the novel genetic strains (the Prediction Set) in Additional file 1: Table S5 with all DE vectors that satisfy F C 1 on the Training Set, from a total of t max number of generations. The range of phenotypic predictions (S) is computed as the number of unique rows in P. With Scheme 8, the diversity of the initial population of parameter vectors is enhanced with V max (biased selection for enhancing the volume spanned by the population) and S max (biased selection for enhancing the range of population’s phenotypic predictions)