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Table 1 Phosphorylation and dephosphorylation reactions that induce synthetic lethality upon their elimination

From: Predicting network modules of cell cycle regulators using relative protein abundance statistics

Eliminated reaction Single mutation strains that are viable before and
(rate constant) inviable after setting the rate constant to zero
Whi5 phosphorylation by Bck2 (k p i5k2) cln3 Δ, Multicopy BCK2, cdh1 Δ, sic1 Δ, swi5 Δ,
  CLB5-db Δ, net1-ts, GAL-CLB2, APC-A
CKI phosphorylation by Cln2 (e k i,n2) bck2 Δ, GAL-SIC1, net1-ts, APC-A
CKI phosphorylation by Clb2 (e k i,b2) GAL-CLN3, cdh1 Δ, GAL-CLB5, CLB1 clb2 Δ
CKI dephosphorylation by Cdc14 (k d p k i,14) bck2 Δ, cdh1 Δ, GAL-CLB2, APC-A
Whi5 phosphorylation by Cln3 (k p i5n3) bck2 Δ, cdh1 Δ, APC-A
SBF phosphorylation by Clb2 (k p b f b2) cdh1 Δ, CLB5-db Δ, APC-A
Whi5 phosphorylation by Cln2 (k p i5n2) bck2 Δ, APC-A
Whi5 dephosphorylation by Cdc14 (k d p i514) APC-A
Net1 dephosphorylation by PPX (k d p n e t,p x ) Multicopy CDC15
  1. Upon setting a phosphorylation or dephosphorylation rate constant to zero as specified in the left column, viability is lost in several single mutation strains (specified in the right column). These rate constants are eliminated to create the single, double, and triple mutants (a total of 129 novel mutant strains in the Prediction Set). The phenotypes and the relative abundances of species in these mutant simulations are the predictions of the model