Predicting network modules of cell cycle regulators using relative protein abundance statistics

BMC Systems Biology

Table 3 The ten most critical model parameters

Parameter name
Total amount of Cdc14
SPN synthesis rate
Total amount of Esp1
Total amount of Net1
Degradation rate of Cdc20
PPX inactivation by Esp1
Efficiency of Cdc14-Net1 complex (RENT) formation
Time scale for protein activation
Net1 phosphorylation by Clb2
Total amount of Mcm1

Based on the sensitivity analysis in [22], the listed model parameters had the largest effects on the objective function (number of phenotypes captured by the model) upon perturbations. Criticality decreases from top to bottom

ISSN: 1752-0509