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Fig. 3 | BMC Systems Biology

Fig. 3

From: Dynamic proteomics reveals bimodal protein dynamics of cancer cells in response to HSP90 inhibitor

Fig. 3

Several proteins show bimodal dynamics, increasing in some cells and decreasing in others, in a way that correlates strongly with cell survival or death. a Most proteins show dynamics which is unimodal–all cells follow the mean, with about two-fold variation around the mean. Shown are retromer VSP26, and the enzyme ENO1. b 25 proteins have bimodal dynamics. Some cells show a decrease in protein levels (dark blue); other cells show an increase after 12 h (red). Shown are the oncogene DDX5 and the mitotic spindle protein STMN1. c STMN1 dynamics correlate with cell survival or killing: cells in which STMN1 increases are preferentially killed. Surviving cells are in light blue, killed cells in red. d Histogram of slopes of STMN1 protein accumulation in the last 10 h (slope of linear regression of protein level as a function of time). Cells with a large slope (increase) preferentially are killed. e DDX5 dynamics correlate in an inverse way with survival or killing: cells in which DDX5 increases preferentially survive to the end of the movie. Surviving cells are in light blue, killed cells in red. f Histogram of slopes of DDX5 protein accumulation in the last 10 h (slope of linear regression of protein level as a function of time). Cells with a large slope (increase) preferentially survive

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