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Table 1 list of Proteins used in this study, functional annotation based on Genecards [], and dynamic profile classification. Down–decrease in time, Down-up decrease in first 12 h followed by increase, up–increase over time

From: Dynamic proteomics reveals bimodal protein dynamics of cancer cells in response to HSP90 inhibitor

Protein name Description Dynamics
CKS2 CDC28 protein kinase, down regulated by p53, G1/S phase transition Up
BAG1 blocks apoptosis, enhances anti-apoptotic effects of BCL2, Inhibits chaperone activity
VPS26A retromer complex, retrieve lysosomal enzyme receptors from endosomes to the Golgi
H2AFV H2A histone protein, nucleosome assembly Down-up
UBE2K ubiquitin enzyme E2, p53 degradation, NRF2 Oxidative Stress Response
CACYBP ubiquitin degradation, beta-catenin degradation, positive regulation of DNA replication
RAB11A RAS oncogene, membrane delivery during cytokinesis, protein transport, endocytosis
TXN Upregulate JUN & NFkB, apoptosis
STMN1 destabilizing microtubules, mitotic spindle organization, activated by ERK
STK24 serine/threonine kinase, apoptosis, upstream (MAPK) cascade
RPS3A ribosomal protein, translation, induction of apoptosis (BCL2 regulation)
TXNRD1 response to oxidative stress, induces actin &tubulin polymerization, cell death
FSCN1 actin-bundling protein, cell motility & migration, cell proliferation
RBX1 E3 ubiquitin ligase, cell cycle progression, DNA repair
SUMO1 ubiquitin-like, DNA repair, upregulate P53, nuclear transport, apoptosis, protein stability
PAK2 p21 activated kinase, cytoskeleton reorganization, anti apoptosis
TBCA tubulin folding, stabilizing beta-tubulin
SPCS1 proteolysis, metabolic process, removes signal peptides from proteins in the ER
PRKAR2A kinase, cAMP-dependent, lipid&glucose metabolism, signaling of GPCR, anti apoptosis
CALM2 regulates the centrosome cycle and cytokinesis
MAPK1 Proliferation, transformation- also known as ERK2, kinase
IL3RA interleukin 3 receptor, Immune response IL-3, Apoptosis, Jak-STAT signaling pathway
PLEC1 intermediate filaments with MT & microfilaments, apoptosis, cell junction assembly
PTPN11 Phosphatase, an upstream activator of Src & ras, Proliferation, transformation
BAG2 BCL2-associated, Inhibits chaperones, apoptosis
PCMTD2 protein modification, protein-L-isoaspartate(D-aspartate)O-methyltransferase domain
VIL2 ezrin, intermediate between the PM and actin cytoskeleton, activate MET with CD44
APAF1 initiates apoptosis
MAP2K2 kinase, Activates the ERK1 and ERK2, Proliferation, transformation
RFC1 replication & repair factor, subunit DNA polymerase, S phase of mitotic cell cycle
TJP1 tight junction protein, apoptosis
EEF2 elongation factor, protein synthesis
DDX5 RNA helicases, splicing, cellular growth and division, P53 TF
PSMB4 proteasome, cell cycle checkpoint
MAPKAP1 mTORC2 Subunit, regulates cell growth & survival, regulate the actin cytoskeleton
ENO1 Enolase, glycolysis, growth control, hypoxia tolerance, receptor, down regulate myc
PBX3 Transcriptional activator that binds the sequence 5-ATCAATCAA-3
RPL11 ribosomal protein L11, rRNA processing, translation
LMNA nuclear membrane fibrous, apoptosis, During mitosis disassembled, nuclear stability
CDKN3 cell cycle arrest
RPS3 ribosomal protein, translation, induction of apoptosis, repair UV-induced DNA damage
FBL snRNP, pre-r/tRNA processing, physical interaction with DDX5, coexpress with NCL
AKAP8L nuclear envelope breakdown & chromatin condensation. initiation of DNA replication
PSMC4 proteasome cell cycle checkpoint Down
HDAC2 histone deacetylase, cell growth arrest, differentiation and death
PSMB7 proteasome cell cycle checkpoint
PDCD5 induction of apoptosis
RRAS Regulates the organization of the actin cytoskeleton, RAS related, activates RAF
DNMT1 CpG methylation, activated by JUN, STAT3, involved in P53 AKT paths
K-alpha-1 tubulin, alpha 1b
HMGA2 negative transcription regulation, chromatin organization, G1/S and G2/M transitions
ARL3 cytokinesis and cilia signaling, microtubule binding, intracellular protein transport
VCL (F-actin)-binding protein, cell-matrix & cell-cell adhesion, cell morphology, locomotion
CD44 MET activation, wound healing, inflammatory response, cell adhesion
PSMA1 proteasome, cell cycle checkpoint, Immune response
PGK1 phosphoglycerate kinase, glycolytic enzyme
ILF2 immune response
RPL22 ribosomal protein, component of the 60S subunit
PPP1R2 carbohydrate metabolic process, phosphatase
PKN1 JUN kinase activity, regulation of the actin cytoskeleton, TF
HMGA1 regulation of transcription
PTTG1 protein import into nucleus
NPM1 chaperoning, histone assembly, cell proliferation, regulation of p53/TP53, ARF
NASP transporting histones into the nucleus, cell proliferation
PFDN5 chaperone
HAT1 internal protein A.A. acetylation, DNA packaging, HMGB1 signaling, DNA repair
STK4 pro apoptosis regulator
RTN4 pro apoptosis regulator
PAWR PRKC, pro apoptosis regulator
SLBP histone mRNA 3-end processing, mRNA export from nucleus
CFLAR CASP8 pro apoptosis gene
YT521 RNA splicing (May be part of a signaling and alternative splicing)
ANXA2 Calcium-regulated membrane-binding protein, signal transduction
DNCH1 Microtubule molecular motors-cytoplasmatic.