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Table 4 The top most different transcription factors detected between IDH-mutant and IDH-wildtype in the REMBRANDT dataset

From: Detection of statistically significant network changes in complex biological networks

TF

Z-score

GHD

μ

MRA fdr

MGA

0.000

1.000

1.000

2.166E-03

TEAD1

0.000

1.000

1.000

8.017E-04

FOS

0.000

1.000

1.000

5.137E-04

JUNB

0.000

1.000

1.000

5.137E-04

MEF2C

0.015

0.015

0.015

8.001E-04

LEF1

0.058

0.014

0.014

5.137E-04

NEUROD2

0.096

0.016

0.016

1.221E-03

EGR2

0.110

0.013

0.013

6.263E-03

JUN

0.123

0.333

0.500

5.137E-04

ARX

0.144

0.012

0.012

9.301E-02

BBX

0.173

0.012

0.012

7.333E-04

TCF3

0.198

0.011

0.011

5.137E-04

LHX6

0.205

0.017

0.017

8.492E-04

EGR1

0.211

0.011

0.011

9.696E-03

BCL6B

0.214

0.011

0.011

5.137E-04

E2F2

0.217

0.011

0.011

7.786E-04

E2F7

0.220

0.012

0.012

5.137E-04

E2F8

0.223

0.012

0.012

5.137E-04

ELF4

0.226

0.012

0.012

5.137E-04

ETV5

0.229

0.013

0.012

5.137E-04

FLI1

0.232

0.013

0.013

5.137E-04

FOXG1

0.235

0.013

0.013

1.000E+00

HOXD9

0.239

0.014

0.014

9.728E-04

ID4

0.242

0.014

0.014

7.786E-04

IRF8

0.246

0.014

0.014

2.393E-02

MYBL2

0.250

0.015

0.015

5.137E-04

NFIA

0.254

0.015

0.015

4.085E-03

NFIB

0.258

0.016

0.016

7.796E-04

KLF13

0.258

0.360

0.515

8.001E-04

OLIG2

0.262

0.016

0.016

7.893E-02

PROX1

0.266

0.017

0.017

1.020E-02

SOX2

0.270

0.017

0.017

2.995E-03

TEF

0.275

0.018

0.018

8.221E-04

ZBTB7A

0.280

0.019

0.018

7.700E-04

ZIC1

0.284

0.019

0.019

7.700E-01

SOX13

0.295

0.021

0.020

8.086E-04

TCF7L2

0.300

0.021

0.021

7.487E-04

BCL6

0.305

0.022

0.022

5.137E-04

MAF

0.317

0.024

0.024

5.137E-04

CEBPB

0.330

0.024

0.024

5.137E-04

CEBPD

0.337

0.025

0.025

5.137E-04

HLF

0.344

0.018

0.018

3.029E-03

ELK1

0.349

0.025

0.025

8.017E-04

FOXJ3

0.369

0.027

0.026

5.137E-04

MTF1

0.377

0.028

0.027

5.137E-04

TP53

0.388

0.028

0.028

5.137E-04

GABPA

0.407

0.030

0.029

5.137E-04

CDC5L

0.417

0.031

0.031

7.899E-04

RORA

0.422

0.329

0.467

7.796E-04

IRF9

0.426

0.031

0.031

3.062E-03

STAT1

0.437

0.033

0.032

5.137E-04

CREB1

0.456

0.035

0.034

5.137E-04

SOX10

0.462

0.036

0.035

8.250E-04

HOXD1

0.475

0.038

0.037

5.137E-04

SOX8

0.479

0.038

0.037

1.760E-03

HOXD11

0.480

0.047

0.046

2.975E-02

NR2F2

0.490

0.042

0.041

5.186E-04

DLX1

0.491

0.046

0.045

7.700E-04

TCF12

0.493

0.040

0.040

9.117E-04

THRB

0.495

0.051

0.050

9.850E-04

DLX2

0.496

0.045

0.044

8.492E-04

HOXD10

0.498

0.050

0.049

5.137E-04

ATF5

0.505

0.057

0.055

5.137E-04

STAT4

0.515

0.055

0.054

9.220E-04

TBR1

0.519

0.020

0.020

9.272E-04

MESP1

0.521

0.092

0.087

8.746E-04

POU3F2

0.523

0.063

0.061

5.137E-04

TFEC

0.530

0.082

0.079

5.137E-04

TCF4

0.533

0.071

0.069

7.487E-04

ETS2

0.543

0.176

0.163

9.728E-04

CREM

0.558

0.110

0.104

5.140E-04

TP63

0.561

0.105

0.099

9.220E-04

STAT6

0.563

0.091

0.087

5.137E-04

NPAS2

0.575

0.136

0.127

1.889E-01

GLI3

0.601

0.313

0.455

4.663E-02

  1. The columns reports the differential measures in terms of Z-score of the proposed differencing test (Eq. (2)), the GHD computed between the two networks, the mean of the null GHD distribution. The last column reports the False Discovery Rate of the GSEA enrichment obtained with a Master Regulator Analysis