Fig. 4

Model validation results for DHF (left) and DF (right) patients at 96 h from onset of fever. H1 refers to the Hamacher result of S1P and IL-1β and H2 refers to the Hamacher result of TNF-α, PAF and IL-10. In the scale, values closer to 1 (blue shaded area) represent non severe (DF) region and the scale values closer to 0 (red shaded area) represent severe region (DHF). The ambiguous region in where it is difficult to make a precise decision as to whether the patient is heading towards severe or non-severe region is indicated in the white region. The black dots represent the model output result of each patient and the severity level can be determined depending on the region the patient falls into. For the figure on left (DHF) we expect more patients to fall in the red shaded area while for the figure on right (DF) we expect more patients to fall in the blue shaded area