TY - JOUR AU - Park, Chihyun AU - Yun, So Jeong AU - Ryu, Sung Jin AU - Lee, Soyoung AU - Lee, Young-Sam AU - Yoon, Youngmi AU - Park, Sang Chul PY - 2017 DA - 2017/03/15 TI - Systematic identification of an integrative network module during senescence from time-series gene expression JO - BMC Systems Biology SP - 36 VL - 11 IS - 1 AB - Cellular senescence irreversibly arrests growth of human diploid cells. In addition, recent studies have indicated that senescence is a multi-step evolving process related to important complex biological processes. Most studies analyzed only the genes and their functions representing each senescence phase without considering gene-level interactions and continuously perturbed genes. It is necessary to reveal the genotypic mechanism inferred by affected genes and their interaction underlying the senescence process. SN - 1752-0509 UR - https://doi.org/10.1186/s12918-017-0417-1 DO - 10.1186/s12918-017-0417-1 ID - Park2017 ER -