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Fig. 3 | BMC Systems Biology

Fig. 3

From: Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast

Fig. 3

Topological and biological properties of KPs in the different layers of the KP-Net. Distribution of (a) in-degree and (b) out-degree of KPs in each layer of the KP-Net and percentage of KPs representing (c) hubs, (d) bottlenecks, (e) shared components between pathways (KPs involved in at least two pathways), and (f) essential genes in each layer of the KP-Net. The broken line in bar plots represents the expected mean of the corresponding percentage in each layer. Black diamonds in box plots designate the average of the corresponding property of KPs. Outliers were omitted from box plots to simplify data representation. P-values were calculated by comparing property means of two layers and the enrichment/depletion of a property within a layer using the RT (Methods) and HT, respectively. For description of the used datasets see Supplementary Materials in Additional file 1

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