TY - JOUR AU - Massagué, J. PY - 1990 DA - 1990// TI - The transforming growth factor- β family JO - Annu Rev Cell Biol VL - 6 UR - https://doi.org/10.1146/annurev.cb.06.110190.003121 DO - 10.1146/annurev.cb.06.110190.003121 ID - Massagué1990 ER - TY - JOUR AU - Clarke, D. C. AU - Liu, X. PY - 2008 DA - 2008// TI - Decoding the quantitative nature of TGF- β/Smad signaling JO - Trends Cell Biol VL - 18 UR - https://doi.org/10.1016/j.tcb.2008.06.006 DO - 10.1016/j.tcb.2008.06.006 ID - Clarke2008 ER - TY - JOUR AU - Shi, Y. AU - Massagué, J. PY - 2003 DA - 2003// TI - Mechanisms of TGF- β signaling from cell membrane to the nucleus JO - Cell VL - 113 UR - https://doi.org/10.1016/S0092-8674(03)00432-X DO - 10.1016/S0092-8674(03)00432-X ID - Shi2003 ER - TY - JOUR AU - Feng, X. H. AU - Derynck, R. PY - 2005 DA - 2005// TI - Specificity and versatility in TGF- β signaling through Smads JO - Annu Rev Cell Dev Biol VL - 21 UR - https://doi.org/10.1146/annurev.cellbio.21.022404.142018 DO - 10.1146/annurev.cellbio.21.022404.142018 ID - Feng2005 ER - TY - JOUR AU - Jenkins, G. PY - 2008 DA - 2008// TI - The role of proteases in transforming growth factor- β activation JO - Int J Biochem Cell Biol VL - 40 UR - https://doi.org/10.1016/j.biocel.2007.11.026 DO - 10.1016/j.biocel.2007.11.026 ID - Jenkins2008 ER - TY - JOUR AU - Massagué, J. AU - Seoane, J. AU - Wotton, D. PY - 2005 DA - 2005// TI - Smad transcription factors JO - Genes Dev VL - 19 UR - https://doi.org/10.1101/gad.1350705 DO - 10.1101/gad.1350705 ID - Massagué2005 ER - TY - JOUR AU - ten Dijke, P. AU - Miyazono, K. AU - Heldin, C. H. PY - 2000 DA - 2000// TI - Signaling inputs converge on nuclear effectors in TGF- β signaling JO - Trends Biochem Sci VL - 25 UR - https://doi.org/10.1016/S0968-0004(99)01519-4 DO - 10.1016/S0968-0004(99)01519-4 ID - ten Dijke2000 ER - TY - JOUR AU - Massagué, J. PY - 1998 DA - 1998// TI - TGF- β signal transduction JO - Ann Rev Biochem VL - 67 UR - https://doi.org/10.1146/annurev.biochem.67.1.753 DO - 10.1146/annurev.biochem.67.1.753 ID - Massagué1998 ER - TY - JOUR AU - Nicolás, F. J. AU - Hill, C. S. PY - 2003 DA - 2003// TI - Attenuation of the TGF- β-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF- β-induced growth arrest JO - Oncogene VL - 22 UR - https://doi.org/10.1038/sj.onc.1206420 DO - 10.1038/sj.onc.1206420 ID - Nicolás2003 ER - TY - JOUR AU - Jenkins, B. J. AU - Grail, D. AU - Nheu, T. AU - Najdovska, M. AU - Wang, B. AU - Waring, P. AU - Inglese, M. AU - McLoughlin, R. M. AU - Jones, S. A. AU - Topley, N. AU - Baumann, H. AU - Judd, L. M. AU - Giraud, A. S. AU - Boussioutas, A. AU - Zhu, H. J. AU - Ernst, M. PY - 2005 DA - 2005// TI - Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF- β signaling JO - Nat Med VL - 11 UR - https://doi.org/10.1038/nm1282 DO - 10.1038/nm1282 ID - Jenkins2005 ER - TY - JOUR AU - Massagué, J. AU - Blain, S. W. AU - Lo, R. S. PY - 2000 DA - 2000// TI - TGF- β signaling in growth control, cancer, and heritable disorders JO - Cell VL - 103 UR - https://doi.org/10.1016/S0092-8674(00)00121-5 DO - 10.1016/S0092-8674(00)00121-5 ID - Massagué2000 ER - TY - JOUR AU - Bachman, K. E. AU - Park, B. H. PY - 2005 DA - 2005// TI - Duel nature of TGF- β signaling: tumor suppressor vs. tumor promoter JO - Curr Opin Oncol VL - 17 UR - https://doi.org/10.1097/01.cco.0000143682.45316.ae DO - 10.1097/01.cco.0000143682.45316.ae ID - Bachman2005 ER - TY - JOUR AU - Leight, J. L. AU - Wozniak, M. A. AU - Chen, S. AU - Lynch, M. L. AU - Chen, C. S. PY - 2012 DA - 2012// TI - Matrix rigidity regulates a switch between TGF- β1-induced apoptosis and epithelial-mesenchymal transition JO - Mol Biol Cell VL - 23 UR - https://doi.org/10.1091/mbc.E11-06-0537 DO - 10.1091/mbc.E11-06-0537 ID - Leight2012 ER - TY - JOUR AU - Ikushima, H. AU - Miyazono, K. PY - 2011 DA - 2011// TI - Biology of transforming growth factor- β signaling JO - Curr Pharm Biotechnol VL - 12 UR - https://doi.org/10.2174/138920111798808419 DO - 10.2174/138920111798808419 ID - Ikushima2011 ER - TY - JOUR AU - Attisano, L. AU - Wrana, J. L. PY - 2002 DA - 2002// TI - Signal transduction by the TGF- β superfamily JO - Sci Signal VL - 296 ID - Attisano2002 ER - TY - JOUR AU - Melke, P. AU - Jönsson, H. AU - Pardali, E. AU - ten Dijke, P. AU - Peterson, C. PY - 2006 DA - 2006// TI - A rate equation approach to elucidate the kinetics and robustness of the TGF- β pathway JO - Biophys J VL - 91 UR - https://doi.org/10.1529/biophysj.105.080408 DO - 10.1529/biophysj.105.080408 ID - Melke2006 ER - TY - JOUR AU - Vilar, J. M. G. AU - Jansen, R. AU - Sander, C. PY - 2006 DA - 2006// TI - Signal Processing in the TGF- β Superfamily Ligand-Receptor Network JO - PLoS Comput Biol VL - 2 UR - https://doi.org/10.1371/journal.pcbi.0020003 DO - 10.1371/journal.pcbi.0020003 ID - Vilar2006 ER - TY - JOUR AU - Clarke, D. C. AU - Brown, M. L. AU - Erickson, R. A. AU - Shi, Y. AU - Liu, X. PY - 2009 DA - 2009// TI - Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics JO - Mol Cell Biol VL - 29 UR - https://doi.org/10.1128/MCB.01443-08 DO - 10.1128/MCB.01443-08 ID - Clarke2009 ER - TY - JOUR AU - Zi, Z. AU - Klipp, E. PY - 2007 DA - 2007// TI - Constraint-Based Modeling and Kinetic Analysis of the Smad Dependent TGF- β Signaling Pathway JO - PLoS ONE VL - 2 UR - https://doi.org/10.1371/journal.pone.0000936 DO - 10.1371/journal.pone.0000936 ID - Zi2007 ER - TY - JOUR AU - Schmierer, B. AU - Tournier, A. L. AU - Bates, P. A. AU - Hill, C. S. PY - 2008 DA - 2008// TI - Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system JO - Proc Natl Acad Sci VL - 105 UR - https://doi.org/10.1073/pnas.0710134105 DO - 10.1073/pnas.0710134105 ID - Schmierer2008 ER - TY - JOUR AU - Chung, S. W. AU - Miles, F. L. AU - Sikes, R. A. AU - Cooper, C. R. AU - Farach-Carson, M. C. AU - Ogunnaike, B. A. PY - 2009 DA - 2009// TI - Quantitative modeling and analysis of the transforming growth factor beta signaling pathway JO - Biophys J VL - 96 UR - https://doi.org/10.1016/j.bpj.2008.11.050 DO - 10.1016/j.bpj.2008.11.050 ID - Chung2009 ER - TY - JOUR AU - Zi, Z. AU - Feng, Z. AU - Chapnick, D. A. AU - Dahl, M. AU - Deng, D. AU - Klipp, E. AU - Moustakas, A. AU - Liu, X. PY - 2011 DA - 2011// TI - Quantitative analysis of transient and sustained transforming growth factor- β signaling dynamics JO - Mol Syst Biol VL - 7 UR - https://doi.org/10.1038/msb.2011.22 DO - 10.1038/msb.2011.22 ID - Zi2011 ER - TY - JOUR AU - Zi, Z. AU - Klipp, E. PY - 2006 DA - 2006// TI - SBML-PET: a Systems Biology Markup Language-based parameter estimation tool JO - Bioinformatics VL - 22 UR - https://doi.org/10.1093/bioinformatics/btl443 DO - 10.1093/bioinformatics/btl443 ID - Zi2006 ER - TY - JOUR AU - Bachmann, J. AU - Raue, A. AU - Schilling, M. AU - Becker, V. AU - Timmer, J. AU - Klingmuller, U. PY - 2012 DA - 2012// TI - Predictive mathematical models of cancer signalling pathways JO - J Intern Med VL - 271 UR - https://doi.org/10.1111/j.1365-2796.2011.02492.x DO - 10.1111/j.1365-2796.2011.02492.x ID - Bachmann2012 ER - TY - JOUR AU - Nakao, A. AU - Imamura, T. AU - Souchelnytskyi, S. AU - Kawabata, M. AU - Ishisaki, A. AU - Oeda, E. AU - Tamaki, K. AU - Hanai, J. AU - Heldin, C. H. AU - Miyazono, K. AU - ten Dijke, P. PY - 1997 DA - 1997// TI - TGF- β receptor-mediated signalling through Smad2, Smad3 and Smad4 JO - EMBO J VL - 16 UR - https://doi.org/10.1093/emboj/16.17.5353 DO - 10.1093/emboj/16.17.5353 ID - Nakao1997 ER - TY - JOUR AU - Li, R. AU - Chung, A. C. AU - Dong, Y. AU - Yang, W. AU - Zhong, X. AU - Lan, H. Y. PY - 2013 DA - 2013// TI - The microRNA miR-433 promotes renal fibrosis by amplifying the TGF- β/Smad3-Azin1 pathway JO - Kidney Int VL - 84 UR - https://doi.org/10.1038/ki.2013.272 DO - 10.1038/ki.2013.272 ID - Li2013 ER - TY - JOUR AU - Kahana, C. PY - 2009 DA - 2009// TI - Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor JO - Essays Biochem VL - 46 UR - https://doi.org/10.1042/bse0460004 DO - 10.1042/bse0460004 ID - Kahana2009 ER - TY - JOUR AU - Liu, L. AU - Santora, R. AU - Rao, J. N. AU - Guo, X. AU - Zou, T. AU - Zhang, H. M. AU - Turner, D. J. AU - Wang, J. Y. PY - 2003 DA - 2003// TI - Activation of TGF- β-Smad signaling pathway following polyamine depletion in intestinal epithelial cells JO - Am J Physiology-Gastrointestinal Liver Physiol VL - 285 UR - https://doi.org/10.1152/ajpgi.00151.2003 DO - 10.1152/ajpgi.00151.2003 ID - Liu2003 ER - TY - JOUR AU - Rao, J. N. AU - Li, L. AU - Bass, B. L. AU - Wang, J. Y. PY - 2000 DA - 2000// TI - Expression of the TGF- β receptor gene and sensitivity to growth inhibition following polyamine depletion JO - Am J Physiology-Cell Physiol VL - 279 ID - Rao2000 ER - TY - JOUR AU - Patel, A. R. AU - Li, J. AU - Bass, B. L. AU - Wang, J. Y. PY - 1998 DA - 1998// TI - Expression of the transforming growth factor- β gene during growth inhibition following polyamine depletion JO - Am J Physiology-Cell Physiol VL - 275 ID - Patel1998 ER - TY - STD TI - Shi F, Zhou P, Wang R. Coupled positive feedback loops regulate the biological behavior. IEEE 2012;169–73. ID - ref31 ER - TY - JOUR AU - Ferrell, J. E. AU - Ha, S. H. PY - 2014 DA - 2014// TI - Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback JO - Trends Biochem Sci VL - 39 UR - https://doi.org/10.1016/j.tibs.2014.09.003 DO - 10.1016/j.tibs.2014.09.003 ID - Ferrell2014 ER - TY - JOUR AU - Ferrell, J. E. AU - Ha, S. H. PY - 2014 DA - 2014// TI - Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity JO - Trends Biochem Sci VL - 39 UR - https://doi.org/10.1016/j.tibs.2014.08.003 DO - 10.1016/j.tibs.2014.08.003 ID - Ferrell2014 ER - TY - JOUR AU - Mitrophanov, A. Y. AU - Groisman, E. A. PY - 2008 DA - 2008// TI - Positive feedback in cellular control systems JO - Bioessays VL - 30 UR - https://doi.org/10.1002/bies.20769 DO - 10.1002/bies.20769 ID - Mitrophanov2008 ER - TY - JOUR AU - Chang, D. E. AU - Leung, S. AU - Atkinson, M. R. AU - Reifler, A. AU - Forger, D. AU - Ninfa, A. J. PY - 2010 DA - 2010// TI - Building biological memory by linking positive feedback loops JO - Proc Natl Acad Sci VL - 107 UR - https://doi.org/10.1073/pnas.0908314107 DO - 10.1073/pnas.0908314107 ID - Chang2010 ER - TY - JOUR AU - Kleeff, J. AU - Ishiwata, T. AU - Maruyama, H. AU - Friess, H. AU - Truong, P. AU - Büchler, M. AU - Falb, D. AU - Korc, M. PY - 1999 DA - 1999// TI - The TGF- β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer JO - Oncogene VL - 18 UR - https://doi.org/10.1038/sj.onc.1202909 DO - 10.1038/sj.onc.1202909 ID - Kleeff1999 ER - TY - JOUR AU - Wagner, J. AU - Keizer, J. PY - 1994 DA - 1994// TI - Effects of rapid buffers on Ca2+ diffusion and Ca2+ oscillations JO - Biophys J VL - 67 UR - https://doi.org/10.1016/S0006-3495(94)80500-4 DO - 10.1016/S0006-3495(94)80500-4 ID - Wagner1994 ER - TY - JOUR AU - Massagué, J. AU - Gomis, R. R. PY - 2006 DA - 2006// TI - The logic of tgf β signaling JO - FEBS Lett VL - 580 UR - https://doi.org/10.1016/j.febslet.2006.04.033 DO - 10.1016/j.febslet.2006.04.033 ID - Massagué2006 ER - TY - JOUR AU - Lee, M. K. AU - Pardoux, C. AU - Hall, M. C. AU - Lee, P. S. AU - Warburton, D. AU - Qing, J. AU - Smith, S. M. AU - Derynck, R. PY - 2007 DA - 2007// TI - Tgf- β activates erk map kinase signalling through direct phosphorylation of shca JO - EMBO J VL - 26 UR - https://doi.org/10.1038/sj.emboj.7601818 DO - 10.1038/sj.emboj.7601818 ID - Lee2007 ER - TY - JOUR AU - Mu, Y. AU - Gudey, S. K. AU - Landström, M. PY - 2012 DA - 2012// TI - Non-smad signaling pathways JO - Cell Tissue Res VL - 347 UR - https://doi.org/10.1007/s00441-011-1201-y DO - 10.1007/s00441-011-1201-y ID - Mu2012 ER - TY - JOUR AU - Wang, X. AU - Li, X. AU - Ye, L. AU - Chen, W. AU - Yu, X. PY - 2013 DA - 2013// TI - Smad7 inhibits tgf- β1-induced mcp-1 upregulation through a mapk/p38 pathway in rat peritoneal mesothelial cells JO - Int Urol Nephrol VL - 45 UR - https://doi.org/10.1007/s11255-012-0350-6 DO - 10.1007/s11255-012-0350-6 ID - Wang2013 ER - TY - JOUR AU - Yu, L. AU - Hébert, M. C. AU - Zhang, Y. E. PY - 2002 DA - 2002// TI - Tgf- β receptor-activated p38 map kinase mediates smad-independent tgf- β responses JO - EMBO J VL - 21 UR - https://doi.org/10.1093/emboj/cdf366 DO - 10.1093/emboj/cdf366 ID - Yu2002 ER - TY - JOUR AU - Wieser, R. AU - Wrana, J. AU - Massagué, J. PY - 1995 DA - 1995// TI - GS domain mutations that constitutively activate T beta RI, the downstream signaling component in the TGF- β receptor complex JO - EMBO J VL - 14 ID - Wieser1995 ER - TY - JOUR AU - Heldin, C. H. AU - Miyazono, K. AU - Ten Dijke, P. PY - 1997 DA - 1997// TI - TGF- β signalling from cell membrane to nucleus through SMAD proteins JO - Nature VL - 390 UR - https://doi.org/10.1038/37284 DO - 10.1038/37284 ID - Heldin1997 ER - TY - JOUR AU - Hayes, S. AU - Chawla, A. AU - Corvera, S. PY - 2002 DA - 2002// TI - TGF β receptor internalization into EEA1-enriched early endosomes role in signaling to Smad2 JO - J Cell Biol VL - 158 UR - https://doi.org/10.1083/jcb.200204088 DO - 10.1083/jcb.200204088 ID - Hayes2002 ER - TY - JOUR AU - Massagué, J. AU - Kelly, B. PY - 1986 DA - 1986// TI - Internalization of transforming growth factor- β and its receptor in BALB/c 3T3 fibroblasts JO - J Cell Physiol VL - 128 UR - https://doi.org/10.1002/jcp.1041280212 DO - 10.1002/jcp.1041280212 ID - Massagué1986 ER - TY - JOUR AU - Zhang, Y. AU - Feng, X. H. AU - Derynck, R. PY - 1998 DA - 1998// TI - Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF- β-induced transcription JO - Nature VL - 394 UR - https://doi.org/10.1038/29814 DO - 10.1038/29814 ID - Zhang1998 ER - TY - JOUR AU - Vincent, T. AU - Neve, E. P. AU - Johnson, J. R. AU - Kukalev, A. AU - Rojo, F. AU - Albanell, J. AU - Pietras, K. AU - Virtanen, I. AU - Philipson, L. AU - Leopold, P. L. PY - 2009 DA - 2009// TI - A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF- β mediated epithelial–mesenchymal transition JO - Nat Cell Biol VL - 11 UR - https://doi.org/10.1038/ncb1905 DO - 10.1038/ncb1905 ID - Vincent2009 ER - TY - BOOK AU - Fall, C. P. PY - 2002 DA - 2002// TI - Computational Cell Biology Interdisciplinary Applied Mathematics; V. 20 PB - Springer-Verlag CY - New York ID - Fall2002 ER - TY - JOUR AU - Luo, K. AU - Lodish, H. PY - 1996 DA - 1996// TI - Signaling by chimeric erythropoietin-TGF- β receptors: homodimerization of the cytoplasmic domain of the type I TGF- β receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction JO - EMBO J VL - 15 ID - Luo1996 ER - TY - JOUR AU - Ebner, R. AU - Chen, R. H. AU - Shum, L. AU - Lawler, S. AU - Zioncheck, T. F. AU - Lee, A. AU - Lopez, A. R. AU - Derynck, R. PY - 1993 DA - 1993// TI - Cloning of a type I TGF- β receptor and its effect on TGF- β binding to the type II receptor JO - Science VL - 260 UR - https://doi.org/10.1126/science.8388127 DO - 10.1126/science.8388127 ID - Ebner1993 ER - TY - JOUR AU - Wu, J. W. AU - Hu, M. AU - Chai, J. AU - Seoane, J. AU - Huse, M. AU - Li, C. AU - Rigotti, D. J. AU - Kyin, S. AU - Muir, T. W. AU - Fairman, R. PY - 2001 DA - 2001// TI - Crystal structure of a phosphorylated Smad2: Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF- β signaling JO - Mol Cell VL - 8 UR - https://doi.org/10.1016/S1097-2765(01)00421-X DO - 10.1016/S1097-2765(01)00421-X ID - Wu2001 ER - TY - JOUR AU - Jenkins, B. J. AU - Grail, D. AU - Nheu, T. AU - Najdovska, M. AU - Wang, B. AU - Waring, P. AU - Inglese, M. AU - McLoughlin, R. M. AU - Jones, S. A. AU - Topley, N. PY - 2005 DA - 2005// TI - Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF- β signaling JO - Nat Med VL - 11 UR - https://doi.org/10.1038/nm1282 DO - 10.1038/nm1282 ID - Jenkins2005 ER - TY - STD TI - Budi EH, Xu J, Derynck R. Regulation of TGF- β Receptors. Methods in molecular biology (Clifton, NJ). 2016; 1344:1. ID - ref54 ER - TY - JOUR AU - Asano, Y. AU - Ihn, H. AU - Yamane, K. AU - Kubo, M. AU - Tamaki, K. PY - 2004 DA - 2004// TI - Impaired smad7-smurf–mediated negative regulation of tgf- β signaling in scleroderma fibroblasts JO - J Clin Investig VL - 113 UR - https://doi.org/10.1172/JCI16269 DO - 10.1172/JCI16269 ID - Asano2004 ER - TY - JOUR AU - Kang, J. S. AU - Liu, C. AU - Derynck, R. PY - 2009 DA - 2009// TI - New regulatory mechanisms of TGF- β receptor function JO - Trends Cell Biol VL - 19 UR - https://doi.org/10.1016/j.tcb.2009.05.008 DO - 10.1016/j.tcb.2009.05.008 ID - Kang2009 ER - TY - JOUR AU - Massagué, J. AU - Attisano, L. AU - Wrana, J. L. PY - 1994 DA - 1994// TI - The TGF- β family and its composite receptors JO - Trends Cell Biol VL - 4 UR - https://doi.org/10.1016/0962-8924(94)90202-X DO - 10.1016/0962-8924(94)90202-X ID - Massagué1994 ER - TY - JOUR AU - Groppe, J. AU - Hinck, C. S. AU - Samavarchi-Tehrani, P. AU - Zubieta, C. AU - Schuermann, J. P. AU - Taylor, A. B. AU - Schwarz, P. M. AU - Wrana, J. L. AU - Hinck, A. P. PY - 2008 DA - 2008// TI - Cooperative assembly of TGF- β superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding JO - Mol Cell VL - 29 UR - https://doi.org/10.1016/j.molcel.2007.11.039 DO - 10.1016/j.molcel.2007.11.039 ID - Groppe2008 ER - TY - JOUR AU - Kingsley, D. M. PY - 1994 DA - 1994// TI - The TGF- β superfamily: new members, new receptors, and new genetic tests of function in different organisms JO - Genes Dev VL - 8 UR - https://doi.org/10.1101/gad.8.2.133 DO - 10.1101/gad.8.2.133 ID - Kingsley1994 ER - TY - JOUR AU - Gunawardena, J. PY - 2014 DA - 2014// TI - Time-scale separation–michaelis and menten’s old idea, still bearing fruit JO - FEBS J VL - 281 UR - https://doi.org/10.1111/febs.12532 DO - 10.1111/febs.12532 ID - Gunawardena2014 ER - TY - JOUR AU - von Gersdorff, G. AU - Susztak, K. AU - Rezvani, F. AU - Bitzer, M. AU - Liang, D. AU - Böttinger, E. P. PY - 2000 DA - 2000// TI - Smad3 and smad4 mediate transcriptional activation of the human smad7 promoter by transforming growth factor β JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.275.15.11320 DO - 10.1074/jbc.275.15.11320 ID - von Gersdorff2000 ER - TY - JOUR AU - Yan, X. AU - Liao, H. AU - Cheng, M. AU - Shi, X. AU - Lin, X. AU - Feng, X. H. AU - Chen, Y. G. PY - 2016 DA - 2016// TI - Smad7 protein interacts with receptor-regulated smads (r-smads) to inhibit transforming growth factor- β (tgf- β)/smad signaling JO - J Biol Chem VL - 291 UR - https://doi.org/10.1074/jbc.M115.694281 DO - 10.1074/jbc.M115.694281 ID - Yan2016 ER - TY - JOUR AU - Ebisawa, T. AU - Fukuchi, M. AU - Murakami, G. AU - Chiba, T. AU - Tanaka, K. AU - Imamura, T. AU - Miyazono, K. PY - 2001 DA - 2001// TI - Smurf1 interacts with transforming growth factor- β type I receptor through Smad7 and induces receptor degradation JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.C100008200 DO - 10.1074/jbc.C100008200 ID - Ebisawa2001 ER - TY - JOUR AU - Kavsak, P. AU - Rasmussen, R. K. AU - Causing, C. G. AU - Bonni, S. AU - Zhu, H. AU - Thomsen, G. H. AU - Wrana, J. L. PY - 2000 DA - 2000// TI - Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation JO - Mol Cell VL - 6 UR - https://doi.org/10.1016/S1097-2765(00)00134-9 DO - 10.1016/S1097-2765(00)00134-9 ID - Kavsak2000 ER - TY - BOOK AU - Khalil, H. K. PY - 1996 DA - 1996// TI - Nonlinear Systems PB - Prentice-Hall CY - New Jersey ID - Khalil1996 ER - TY - JOUR AU - Inman, G. J. AU - Nicolás, F. J. AU - Hill, C. S. PY - 2002 DA - 2002// TI - Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF- β receptor activity JO - Mol Cell VL - 10 UR - https://doi.org/10.1016/S1097-2765(02)00585-3 DO - 10.1016/S1097-2765(02)00585-3 ID - Inman2002 ER - TY - JOUR AU - Fleming, N. I. AU - Jorissen, R. N. AU - Mouradov, D. AU - Christie, M. AU - Palmieri, M. AU - Day, F. AU - Li, S. AU - Tsui, C. AU - Lipton, L. PY - 2013 DA - 2013// TI - SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer JO - Cancer Res VL - 73 UR - https://doi.org/10.1158/0008-5472.CAN-12-2706 DO - 10.1158/0008-5472.CAN-12-2706 ID - Fleming2013 ER - TY - JOUR AU - Wakefield, L. M. AU - Smith, D. M. AU - Masui, T. AU - Harris, C. C. AU - Sporn, M. B. PY - 1987 DA - 1987// TI - Distribution and modulation of the cellular receptor for transforming growth factor- β JO - J Cell Biol VL - 105 UR - https://doi.org/10.1083/jcb.105.2.965 DO - 10.1083/jcb.105.2.965 ID - Wakefield1987 ER - TY - JOUR AU - Laiho, M. AU - Weis, M. AU - Massagué, J. PY - 1990 DA - 1990// TI - Concomitant loss of transforming growth factor (TGF)- β receptor types I and II in TGF- β-resistant cell mutants implicates both receptor types in signal transduction JO - J Biol Chem VL - 265 ID - Laiho1990 ER - TY - JOUR AU - Kimchi, A. AU - Wang, X. F. AU - Weinberg, R. A. AU - Cheifetz, S. AU - Massagué, J. PY - 1988 DA - 1988// TI - Absence of TGF- β receptors and growth inhibitory responses in retinoblastoma cells JO - Science VL - 240 UR - https://doi.org/10.1126/science.2895499 DO - 10.1126/science.2895499 ID - Kimchi1988 ER - TY - JOUR AU - Yu, M. AU - Trobridge, P. AU - Wang, Y. AU - Kanngurn, S. AU - Morris, S. AU - Knoblaugh, S. PY - 2014 DA - 2014// TI - Inactivation of TGF- β signaling and loss of PTEN cooperate to induce colon cancer in vivo JO - Oncogene VL - 33 UR - https://doi.org/10.1038/onc.2013.102 DO - 10.1038/onc.2013.102 ID - Yu2014 ER - TY - JOUR AU - Liu, R. Y. AU - Zeng, Y. AU - Lei, Z. AU - Wang, L. AU - Yang, H. AU - Liu, Z. AU - Zhao, J. AU - Zhang, H. T. PY - 2014 DA - 2014// TI - Jak/stat3 signaling is required for tgf- β-induced epithelial-mesenchymal transition in lung cancer cells JO - Int J Oncol VL - 44 ID - Liu2014 ER - TY - JOUR AU - Pickup, M. AU - Novitskiy, S. AU - Moses, H. L. PY - 2013 DA - 2013// TI - The roles of TGF [beta] in the tumour microenvironment JO - Nat Rev Cancer VL - 13 UR - https://doi.org/10.1038/nrc3603 DO - 10.1038/nrc3603 ID - Pickup2013 ER - TY - JOUR AU - Giampieri, S. AU - Manning, C. AU - Hooper, S. AU - Jones, L. AU - Hill, C. S. AU - Sahai, E. PY - 2009 DA - 2009// TI - Localized and reversible tgf β signalling switches breast cancer cells from cohesive to single cell motility JO - Nat Cell Biol VL - 11 UR - https://doi.org/10.1038/ncb1973 DO - 10.1038/ncb1973 ID - Giampieri2009 ER - TY - JOUR AU - Langenskiöld, M. AU - Holmdahl, L. AU - Falk, P. AU - Angenete, E. AU - Ivarsson, M. L. PY - 2008 DA - 2008// TI - Increased tgf-beta1 protein expression in patients with advanced colorectal cancer JO - J Surg Oncol VL - 97 UR - https://doi.org/10.1002/jso.20961 DO - 10.1002/jso.20961 ID - Langenskiöld2008 ER - TY - JOUR AU - Shariat, S. F. AU - Shalev, M. AU - Menesses-Diaz, A. AU - Kim, I. Y. AU - Kattan, M. W. AU - Wheeler, T. M. AU - Slawin, K. M. PY - 2001 DA - 2001// TI - Preoperative plasma levels of transforming growth factor beta1 (tgf- β1) strongly predict progression in patients undergoing radical prostatectomy JO - J Clin Oncol VL - 19 UR - https://doi.org/10.1200/JCO.2001.19.11.2856 DO - 10.1200/JCO.2001.19.11.2856 ID - Shariat2001 ER - TY - JOUR AU - Xiong, B. AU - Gong, L. L. AU - Zhang, F. AU - Hu, M. B. AU - Yuan, H. Y. PY - 2002 DA - 2002// TI - Tgf beta˜ 1 expression and angiogenesis in colorectal cancer tissue JO - World J Gastroenterol VL - 8 UR - https://doi.org/10.3748/wjg.v8.i3.496 DO - 10.3748/wjg.v8.i3.496 ID - Xiong2002 ER - TY - JOUR AU - Xu, J. AU - Acharya, S. AU - Sahin, O. AU - Zhang, L. AU - Lowery, F. J. AU - Sahin, A. A. AU - Zhang, X. H. -. F. AU - Hung, M. C. AU - Yu, D. PY - 2015 DA - 2015// TI - Abstract lb-202: 14-3-3 ζ turns tgf- β’s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of smad partners from p53 to gli2 JO - Cancer Res VL - 75 UR - https://doi.org/10.1158/1538-7445.AM2015-LB-202 DO - 10.1158/1538-7445.AM2015-LB-202 ID - Xu2015 ER - TY - JOUR AU - Santibanez, J. F. AU - Quintanilla, M. AU - Bernabeu, C. PY - 2011 DA - 2011// TI - TGF- β/TGF- β receptor system and its role in physiological and pathological conditions JO - Clin Sci VL - 121 UR - https://doi.org/10.1042/CS20110086 DO - 10.1042/CS20110086 ID - Santibanez2011 ER - TY - JOUR AU - Anzano, M. AU - Roberts, A. AU - Smith, J. AU - Sporn, M. AU - De Larco, J. PY - 1983 DA - 1983// TI - Sarcoma growth factor from conditioned medium is composed of both type α and type β transforming growth factors JO - Proc Natl Acad Sci U S A VL - 80 UR - https://doi.org/10.1073/pnas.80.20.6264 DO - 10.1073/pnas.80.20.6264 ID - Anzano1983 ER - TY - JOUR AU - De Larco, J. E. AU - Todaro, G. J. PY - 1978 DA - 1978// TI - Growth factors from murine sarcoma virus-transformed cells JO - Proc Natl Acad Sci VL - 75 UR - https://doi.org/10.1073/pnas.75.8.4001 DO - 10.1073/pnas.75.8.4001 ID - De Larco1978 ER - TY - JOUR AU - Wagner, J. AU - Ma, L. AU - Rice, J. AU - Hu, W. AU - Levine, A. AU - Stolovitzky, G. PY - 2005 DA - 2005// TI - p53–Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback JO - IEE Proc Syst Biol VL - 152 UR - https://doi.org/10.1049/ip-syb:20050025 DO - 10.1049/ip-syb:20050025 ID - Wagner2005 ER - TY - JOUR AU - Wagner, J. AU - Stolovitzky, G. PY - 2008 DA - 2008// TI - Stability and time-delay modeling of negative feedback loops JO - Proc IEEE VL - 96 UR - https://doi.org/10.1109/JPROC.2008.925427 DO - 10.1109/JPROC.2008.925427 ID - Wagner2008 ER - TY - JOUR AU - Duffy, I. AU - Varacallo, P. AU - Klerk, H. AU - Hawker, J. PY - 2015 DA - 2015// TI - Endothelial and cancer cells have differing amounts of tgf beta receptors involved in angiogenesis JO - FASEB J VL - 29 ID - Duffy2015 ER - TY - JOUR AU - Hansson, G. K. AU - Libby, P. PY - 2006 DA - 2006// TI - The immune response in atherosclerosis: a double-edged sword JO - Nat Rev Immunol VL - 6 UR - https://doi.org/10.1038/nri1882 DO - 10.1038/nri1882 ID - Hansson2006 ER - TY - JOUR AU - Akhurst, R. J. AU - Derynck, R. PY - 2001 DA - 2001// TI - TGF- β signaling in cancer–a double-edged sword JO - Trends Cell Biol VL - 11 UR - https://doi.org/10.1016/S0962-8924(01)02130-4 DO - 10.1016/S0962-8924(01)02130-4 ID - Akhurst2001 ER - TY - JOUR AU - Chen, B. S. AU - Wu, C. C. PY - 2012 DA - 2012// TI - On the calculation of signal transduction ability of signaling transduction pathways in intracellular communication: systematic approach JO - Bioinformatics VL - 28 UR - https://doi.org/10.1093/bioinformatics/bts159 DO - 10.1093/bioinformatics/bts159 ID - Chen2012 ER - TY - BOOK AU - Choi, S. PY - 2010 DA - 2010// TI - Systems Biology Approaches: Solving New Puzzles in a Symphonic Manner. Systems Biology for Signaling Networks PB - Springer CY - New York ID - Choi2010 ER - TY - JOUR AU - Kavsak, P. AU - Rasmussen, R. K. AU - Causing, C. G. AU - Bonni, S. AU - Zhu, H. AU - Thomsen, G. H. AU - Wrana, J. L. PY - 2000 DA - 2000// TI - Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFbeta Receptor for Degradation JO - Mol Cell VL - 6 UR - https://doi.org/10.1016/S1097-2765(00)00134-9 DO - 10.1016/S1097-2765(00)00134-9 ID - Kavsak2000 ER - TY - JOUR AU - Di Guglielmo, G. M. AU - Le Roy, C. AU - Goodfellow, A. F. AU - Wrana, J. L. PY - 2003 DA - 2003// TI - Distinct endocytic pathways regulate TGF- β receptor signalling and turnover JO - Nat Cell Biol VL - 5 UR - https://doi.org/10.1038/ncb975 DO - 10.1038/ncb975 ID - Di Guglielmo2003 ER -