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Fig. 1 | BMC Systems Biology

Fig. 1

From: Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching

Fig. 1

The full TGF-β signalling biological model. Potential phosphorylation sites of the receptors are specified with empty circles attached to R1 and R2 components. Arrows pointing to 6 blue dots represent degradation process. The stars indicate the production processes for specific proteins on the membrane and in the cytoplasm. The red solid arrows originating from SMAD7/Smurf apply negative and/or positive feedback on the receptor components of the membrane. Oval-shaped components written in small letters represent micro-RNAs. In this figure, S represents the SMAD proteins. Note that the arrow from ODC to polyamine shows an stimulatory reaction rather than conversion

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