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Fig. 4 | BMC Systems Biology

Fig. 4

From: Quantitative evaluation and reversion analysis of the attractor landscapes of an intracellular regulatory network for colorectal cancer

Fig. 4

Probable cancer reversion targets identified from the single node perturbation. a Eleven probable cancer reversion targets with three types of perturbation, including activation, inhibition, and restoration, are listed (left). Seven of them are listed with the supporting evidence (right). b Double node perturbation simulation has revealed three synergistic pairs (blue) which were selected when the increase of normal-like score for two node perturbation is larger than the sum of each increase of normal-like score of single node perturbation. c The functional network motif related with synergistic pairs. The identified motif is a functional unit of EGF signal transduction which contains EGF and its downstream nodes

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