Fig. 5

Four stable motifs of eleven cancer reversion targets. a All of the four motifs are relevant to the signal transduction pathways that are closely involved in colorectal cancer progression. b Changes of node activities for APC restoration in each motif. For APC mutation or restoration, the average expression level of some molecules is robustly fixed to 1 (red) or 0 (blue) regardless of external signals. However, the activities of some other nodes can fluctuate according to external signals, and thus show 0.5 (purple) on average