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Fig. 6 | BMC Systems Biology

Fig. 6

From: A mathematical model of mechanotransduction reveals how mechanical memory regulates mesenchymal stem cell fate decisions

Fig. 6

The MSC network precludes multistability when feedback loops are blocked. Shown are the steady states of TUBB3 (a), PPARG (b), MYOD1 (c), and RUNX2 (d) under different stiffness values. In each figure the x-axis denotes the stiffness and the y-axis denotes the relative expression levels of specific lineage genes at steady states (black lines). The blue lines illustrate how the relative gene expression at the steady state changes as the stiffness increases. The red lines illustrate how the relative gene expression level at the steady state changes as the stiffness decreases

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