Table 1 The references of regulatory interactions in the network

1

YAP/TAZ is identified as mechanical sensors and mediators.

Halder, G et al, 2012; Dupont S. et al. 2011. [6, 18]

3

The inhibition of TUBB3 can be attenuated by YAP depletion.

Alarcon, C et al. 2009 [65]

5

PPARG can be bound to TAZ, which results in transcription inhibitions from the aP2 promoter.

Hong, J.H. et al, 2006.[21]

7

TAZ functions as an enhancer of MYOD-mediated myogenic differentiation.

Jeong, H. et al, 2010. [66]

9

RUNX2 has binding domain to TAZ for osteocalcin expression.

Hong, J.H. et al, 2006. Hong, J.H. et al, 2005 [20, 21]

10,11,12,13

Increased cell spreading results in higher stiffness sensitivity via increased binding of integrins to the ECM.

Halder G et al, 2012. Sun Y et al, 2012. Bernabe B P et al, 2016. [6, 17, 67]

2,4,6,8

These arrows are necessary for the dynamics of TUBB3, PPARG, MYOD1, and RUNX2 on all possible stiffness environment since TUBB3, PPARG, MYOD1, and RUNX2 are expressed only on the super soft stiffness (< 1 kPa), the soft stiffness (~1 kPa), the medium stiffness (~10 kPa), and the high stiffness (~40 kPa) environment respectively.

Engler, A.J. et al,2006; Halder G et al, 2012 [1, 6]