From: Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient
 | #1 | #2 | #3 | #4 | #5 | #6 | #7 | #8 | #9 | #10 | CV |
---|---|---|---|---|---|---|---|---|---|---|---|
Optimization algorithmsa | SRES | SRES HJ | PS | SRES HJ Praxis | GA SRES | SRES | SRES GA GASR | SRES | GA HJ | SRES | Â |
Sum squares | 0.01906 | 0.01906 | 0.01908 | 0.01909 | 0.01918 | 0.01917 | 0.01937 | 0.01943 | 0.01970 | 0.01975 | Â |
kInDuo (d -1 ) | 0.236 | 0.251 | 0.322 | 0.131 | 0.250 | 0.0690 | 0.158 | 0.134 | 0.0381 | 0.0347 | 61.1% |
kInLiver (d -1 ) | 9.40 | 9.99 | 12.7 | 5.35 | 10.3 | 2.98 | 6.83 | 5.72 | 1.69 | 1.55 | 58.3% |
kInRBC (d -1 ) | 1.09 | 1.09 | 1.10 | 1.09 | 1.08 | 1.08 | 1.04 | 1.07 | 1.19 | 1.20 | 4.64% |
kInRest (d -1 ) | 18.3 | 19.4 | 24.7 | 10.4 | 22.0 | 6.16 | 13.9 | 11.3 | 3.20 | 2.95 | 58.6% |
kInBM (d -1 ) | 49.5 | 52.7 | 67.1 | 28.1 | 58.8 | 15.8 | 35.3 | 29.7 | 9.07 | 8.26 | 59.1% |
kDuoLoss (d -1 ) | 5.00.10-4 | 5.45.10-4 | 5.05.10-4 | 9.29.10-4 | 0.00359 | 0.0270 | 0.0313 | 9.38.10-4 | 0.00150 | 0.00150 | 173% |
kRestOut (d -1 ) | 0.0238 | 0.0239 | 0.0239 | 0.0238 | 0.0234 | 0.0236 | 0.0234 | 0.0236 | 0.0236 | 0.0234 | 0.851% |
kBMSpleen (d -1 ) | 0.173 | 0.173 | 0.183 | 0.143 | 0.0453 | 0.0619 | 0.0680 | 0.0900 | 0.0585 | 0.0567 | 53.3% |
VDuoNTBI (mol d -1 ) | 2.03 | 11.4 | 3.56 | 0.792 | 0.910 | 0.200 | 0.200 | 0.901 | 0.0978 | 0.566 | 167% |
VLiverNTBI (mol d -1 ) | 0.551 | 3.15 | 0.982 | 0.203 | 0.0946 | 0.0261 | 0.0295 | 0.204 | 0.00847 | 0.0937 | 181% |
VSpleenNTBI (mol d -1 ) | 35.5 | 202 | 63.9 | 12.6 | 4.86 | 1.342 | 1.49 | 10.9 | 0.434 | 3.89 | 185% |
VRestNTBI (mol d -1 ) | 0.350 | 2.01 | 0.634 | 0.121 | 0.0212 | 0.0109 | 0.0128 | 0.102 | 0.00119 | 0.0114 | 191% |
vRBCSpleen (d -1 ) | 0.0833 | 0.0831 | 0.0870 | 0.0706 | 0.0132 | 0.0235 | 0.0283 | 0.043 | 0.0209 | 0.0190 | 64.4% |
Km (M) | 0.239 | 1.38 | 0.412 | 0.100 | 0.128 | 0.0159 | 0.0145 | 0.119 | 0.00850 | 0.117 | 164% |
vDiet (M d -1 ) | 0.0042 | 0.0042 | 0.0042 | 0.0042 | 0.00318 | 0.00377 | 0.00397 | 0.0042 | 0.0042 | 0.0042 | 8.25% |
kNTBI_Fe1Tf (M -1 d -1 ) | 5.107 | 5.107 | 5.107 | 5.107 | 4.98.106 | 1.08.109 | 5.25.108 | 5.107 | 5.107 | 5.107 | 176% |
kFe1Tf_Fe2Tf (M -1 d -1 ) | 5.107 | 5.107 | 5.107 | 5.107 | 10.1 | 1.08.109 | 5.25.108 | 5.107 | 5.107 | 5.107 | 177% |
TF saturation (%) | 46.6 | 43.7 | 36.0 | 70.0 | 7.15 | 47.0 | 25.1 | 43.7 | 70.0 | 70.0 | Â |
Total Fe (mg) | 2.01 | 2.01 | 2.00 | 2.04 | 2.20 | 2.20 | 2.20 | 2.20 | 2.20 | 2.20 | Â |
RBC trans. Time (d) | 12.0 | 12.0 | 11.5 | 14.2 | 75.9 | 42.5 | 35.3 | 23.3 | 47.9 | 52.6 | Â |