Fig. 3
From: Single-cell study links metabolism with nutrient signaling and reveals sources of variability
Dynamic and NLME modelling of the Snf1/Mig1 pathway. a Schematic representation of the model. The model consists of three main parts, namely the activity of glucose, the activity of Snf1 and the activity of Mig1. b Simulation of the distribution of the random parameters for the HXT1 strain. The columns indicate the extracellular glucose concentration, ranging from 0, 11, 55 to 220 mM which are illustrated from the left to the right in the figure. Each heat map is generated by drawing 50 mixed effect random terms, that is η ∼ N(0, σ), corresponding to the parameter vectors from the generated parameter distributions for the various strains and glucose concentrations. The heat map displays various parameters on the y-axis, the individuals on the x-axis and the magnitude of the random terms are indicated by the colour scale shown above the figure. The colour scale ranges from 0 to 2 where a red colour corresponds to a high random term and a blue colour correspond to a low value of the random term. The white fields correspond to the parameters connected to the hexose transporters that are not active in HXT1 strains