Table 1 Environments of the CD4+ T cell regulatory network
Environment | Cytokines | Active nodes |
|---|---|---|
pro-Th0 | no cytokines | None |
pro-Th1 | IFNγ, IL-12 | IFNGe, IL12e |
pro-Th2 | IL-2, IL-4 | IL2e, IL4e |
pro-Th17 | IL-21 (or IL-6), TGFβ | IL21e, TGFBe |
pro-iTreg | IL-2, TGFβ | IL2e, TGFBe |
pro-Tr1 | IL-10, 1 L-27 | IL10e, IL27e |