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Table 2 Differentially expressed genes following α2B-adrenoceptor activation compared with vehicle-treated control according to IPA

From: Gene expression profiles and signaling mechanisms in α2B-adrenoceptor-evoked proliferation of vascular smooth muscle cells

Gene symbol

Gene name

Fold change

P-value

Up-regulated genes

 Lypd8

LY6/PLAUR domain containing 8

2.01

4.2·10−6

 Glrx

glutaredoxin

1.60

1.0·10−3

 LOC500300

similar to hypothetical protein MGC6835 (Depp)

1.58

4.0·10−3

 Procr

protein C receptor

1.56

5.7·10−3

 Egr1

early growth response 1

1.54

5.0·10−3

 Rpl37

ribosomal protein L37

1.51

1.0·10−3

 Kif20a

kinesin family member 20a

1.47

1.3·10−2

 Oasl

2′-5′-oligoadenylate synthetase-like

1.46

5.0·10−3

 Fam25a

family with sequence similarity 25, member A

1.45

4.0·10−3

 Ppial4g

peptidylprolyl isomerase A like 4G

1.45

2.3·10−2

Down-regulated genes

 Cx3cl1

chemokine (C-X3-C motif) ligand 1

−1.86

1.7·10−5

 Ccl2

chemokine (C-C motif) ligand 2

−1.74

4.4·10−4

 Ahnak

AHNAK nucleoprotein

−1.47

2.3·10−2

 Npm3

nucleophosmin/nucleoplasmin 3

−1.45

3.0·10−2

 Nid1

nidogen 1

−1.44

8.7·10−3

 Tnnt2

troponin T2, cardiac type

−1.42

6.0·10−3

 Zfp36l2

zinc finger protein 36, C3H type-like 2

−1.40

4.4·10−2

 Ccl7

chemokine (C-C motif) ligand 7

−1.40

2.0·10−2

 Cav1

caveolin 1

−1.39

8.2·10−3

 Rhoa

ras homolog family member A

−1.38

2.4·10−2