Fig. 8

Comparison of Shape Metrics of Tumors. a Contour plot of the chord length with increasing migration and proliferation rates. Contour plot of the moment of inertia with increasing migration and proliferation rates. Contour plot of the chord ratio metric with increasing migration and proliferation rates. All metrics show that the fingering morphology increases with increasing migration and decreasing proliferation. b The shape metrics indicates the invasiveness of the tumor morphology. We evaluate moment of inertia, days until end of simulation (500,000 cells), chord metric and fractal dimension. MB231 cells under maraviroc (Mara) treatment have statistically significant lower shape metric values than the parent cell lines (Cnt). MB231 cells under hypoxic conditions (Hyp) have statistically significant higher chord metrics than the parent cell lines (Cnt). Simulated maraviroc treated tumors all have statistically significant less invasive morphologies than their parent lines