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Table 3 Summary of parameter values

From: Combination therapy for melanoma with BRAF/MEK inhibitor and immune checkpoint inhibitor: a mathematical model

Notation Description Value used References
\(K_{T_{1}}\) Half-saturation of CD 4+ T cells 2×10−3 g/cm3 Estimated
\(K_{T_{8}}\) Half-saturation of CD 8+ T cells 1×10−3 g/cm3 Estimated
\(K_{T_{r}}\) Half-saturation of Tregs 5×10−4 g/cm3 [65]
K C Half-saturation of tumor cells 0.4 g/cm3 [65]
\(K_{I_{12}}\) Half-saturation of IL-12 8×10−10 g/cm3 Estimated
\(K_{I_{2}}\) Half-saturation of IL-2 2.37×10−11 g/cm3 [65]
\(K_{T_{\beta }}\) Half-saturation of TGF- β 2.68×10−13 g/cm3 Estimated
\(K_{I_{6}}\) Half-saturation of IL-6 3.4×10−11 g/cm3 Estimated
\(K_{I_{10}}\) Half-saturation of IL-10 8.75×10−11 g/cm3 Estimated
\(K^{\prime }_{Q}\) Half-saturation of PD-1-PD-L1 3.54×10−18 g2/cm6 Estimated
K B Half-saturation of BRAF/MEKi 6.69×10−10 g/cm3 Estimated
\(K^{\prime }_{TQ}\) Inhibition of function of T cells by PD-1-PD-L1 1.77×10−18 g2/cm6 Estimated
K CB Inhibition of proliferation of cancer cells by BRAF/MEKi 3.06×10−9 g/cm3 Estimated