Table 3 Summary of parameter values
Notation | Description | Value used | References |
|---|---|---|---|
\(K_{T_{1}}\) | Half-saturation of CD 4+ T cells | 2×10−3 g/cm3 | Estimated |
\(K_{T_{8}}\) | Half-saturation of CD 8+ T cells | 1×10−3 g/cm3 | Estimated |
\(K_{T_{r}}\) | Half-saturation of Tregs | 5×10−4 g/cm3 | [65] |
K C | Half-saturation of tumor cells | 0.4 g/cm3 | [65] |
\(K_{I_{12}}\) | Half-saturation of IL-12 | 8×10−10 g/cm3 | Estimated |
\(K_{I_{2}}\) | Half-saturation of IL-2 | 2.37×10−11 g/cm3 | [65] |
\(K_{T_{\beta }}\) | Half-saturation of TGF- β | 2.68×10−13 g/cm3 | Estimated |
\(K_{I_{6}}\) | Half-saturation of IL-6 | 3.4×10−11 g/cm3 | Estimated |
\(K_{I_{10}}\) | Half-saturation of IL-10 | 8.75×10−11 g/cm3 | Estimated |
\(K^{\prime }_{Q}\) | Half-saturation of PD-1-PD-L1 | 3.54×10−18 g2/cm6 | Estimated |
K B | Half-saturation of BRAF/MEKi | 6.69×10−10 g/cm3 | Estimated |
\(K^{\prime }_{TQ}\) | Inhibition of function of T cells by PD-1-PD-L1 | 1.77×10−18 g2/cm6 | Estimated |
K CB | Inhibition of proliferation of cancer cells by BRAF/MEKi | 3.06×10−9 g/cm3 | Estimated |