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Fig. 1 | BMC Systems Biology

Fig. 1

From: Cooperative binding mitigates the high-dose hook effect

Fig. 1

Binding of ligands A, B to a bivalent linker protein L. a Low linker concentration: availability of L limits the formation of total complexes (LAB, in colour). b Linker concentration on the order of ligand concentration: Formation of fully formed complex (LAB) reaches its maximum. c Concentration of linker L much higher than that of A or B: partially bound forms prevail, and formation of fully formed complex (LAB) goes down in absolute terms

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