TY - JOUR AU - Tian, Bo AU - Zhao, Can AU - Gu, Feiyang AU - He, Zengyou PY - 2017 DA - 2017/09/21 TI - A two-step framework for inferring direct protein-protein interaction network from AP-MS data JO - BMC Systems Biology SP - 82 VL - 11 IS - 4 AB - Affinity purification-mass spectrometry (AP-MS) has been widely used for generating bait-prey data sets so as to identify underlying protein-protein interactions and protein complexes. However, the AP-MS data sets in terms of bait-prey pairs are highly noisy, where candidate pairs contain many false positives. Recently, numerous computational methods have been developed to identify genuine interactions from AP-MS data sets. However, most of these methods aim at removing false positives that contain contaminants, ignoring the distinction between direct interactions and indirect interactions. SN - 1752-0509 UR - https://doi.org/10.1186/s12918-017-0452-y DO - 10.1186/s12918-017-0452-y ID - Tian2017 ER -