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Table 4 The performance comparison on the Combined data set in terms of normalized AUC values

From: A two-step framework for inferring direct protein-protein interaction network from AP-MS data

 

BGS

PCA

Y2H

 

Initial

Filtered(ND)

Filtered(Silencer)

Initial

Filtered(ND)

Filtered(Silencer)

Initial

Filtered(ND)

Filtered(Silencer)

SA

0.81

0.80 ↓

0.79 ↓

0.76

0.73 ↓

0.73 ↓

0.76

0.77 ↑

0.78 ↑

PE

0.63

0.77 ↑

0.76 ↑

0.59

0.74 ↑

0.72 ↑

0.55

0.77 ↑

0.73 ↑

DC

0.54

0.67 ↑

0.68 ↑

0.57

0.67 ↑

0.65 ↑

0.44

0.71 ↑

0.70 ↑

Hart

0.72

0.77 ↑

0.78 ↑

0.70

0.75 ↑

0.75 ↑

0.65

0.74 ↑

0.75 ↑

  1. In the table, the symbol ↑highlights the case that the normalized AUC value is increased in the curve derived from the filtered network. If there is no improvement, then ↓ is used instead