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Fig. 1 | BMC Systems Biology

Fig. 1

From: Glioma cell fate decisions mediated by Dll1-Jag1-Fringe in Notch1 signaling pathway

Fig. 1

System for signal integration in the intracellular and intercellular Notch1 signaling pathway. Notch1, the transmembrane receptor of one cell, binds to Dll1 or Jag1, the transmembrane ligands belonging to the neighboring cell. This trans-interaction leads to the cleavage and release of NICD that regulates the production of the two ligands asymmetrically, i.e., it inhibits Dll1 but activates Jag1. Interaction between Notch1 receptor and ligands (Dll1 or Jag1) of the same cell (cis-interaction) leads to the degradation of both the receptor and the ligands. Glycosylation of Notch1 by Fringe modifies Notch1 to have a higher affinity for binding to Dll1 and a lower affinity for binding to Jag1

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