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Fig. 2 | BMC Systems Biology

Fig. 2

From: Glioma cell fate decisions mediated by Dll1-Jag1-Fringe in Notch1 signaling pathway

Fig. 2

Regulation diagram. Notch1 could interact by cis and trans with Jag1 and Dll1 ligands, and in which one of the Fringe-related proteins, Lunatic Fringe (LFng), could modulate these interactions. LFng modification of Notch1 enhances trans activation from Dll1 and weakens trans-activation from Jag1 (left). LFng modification of Notch1 enhances cis-interactions with Dll1 and weakens cis-interactions with Jag1 (right). Interactions are indicated by + and − for positive and negative regulation, respectively

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