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Fig. 7 | BMC Systems Biology

Fig. 7

From: Glioma cell fate decisions mediated by Dll1-Jag1-Fringe in Notch1 signaling pathway

Fig. 7

Bifurcation diagrams for the effect of Fringe protein. a The bifurcation with a as a control parameter at L=1. The value a reflects the effect of Fringe on cis-inhibition and trans-activation between Notch1 and Dll1. The term k c N 2 J 2 is replaced by 1.2×k c N 2 J 2 in Eq. (28) and the term k t D 1 N 2 is replaced by 42×k t D 1 N 2 in Eq. (29). As a gradually increases, the healthy tissue changes from normal to grade I II of gliomas. When a is increased to a certain value, the state will switch from grade I II to grade III IV of gliomas. b The bifurcation diagram with L as a control parameter at a=1.2, which reflects the dynamics of Notch1 signaling pathway after the addition of Lunatic Fringe. When the Fringe is inhibited, the transition from gliomas to a healthy state can be gradually realized

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