Table 2 Subcellular location and function classification of targeted drug targets
From: A systematic analysis of FDA-approved anticancer drugs
Subcellular location | Family | Subfamily | Number of targets |
|---|---|---|---|
Cytoplasm (27) | |||
| Â | Enzyme (23) | E3 ligase | 1 |
Epigenetic enzyme | 1 | ||
Monooxygenases | 2 | ||
Peptidase | 6 | ||
Phosphatidyl Inositol Kinases | 1 | ||
Serine/threonine kinase | 5 | ||
Threonine/tyrosine-protein kinase | 2 | ||
Tyrosine kinase | 5 | ||
Other (4) | Other | 4 | |
Extracellular space (7) | |||
| Â | Cytokine (1) | Cytokine | 1 |
Enzyme (1) | Phosphatase | 1 | |
Growth factor (4) | Growth factor | 4 | |
Hormone (1) | Hormone | 1 | |
Nucleus (23) | |||
| Â | Enzyme (13) | Epigenetic enzyme | 4 |
Polymerase | 3 | ||
Ribonucleotide diphosphate reductase | 1 | ||
Serine/threonine kinase | 3 | ||
Tyrosine kinase | 2 | ||
Receptor(10) | Ligand-dependent nuclear receptor | 10 | |
Plasma membrane (45) | |||
| Â | Antigen (5) | Antigen | 5 |
Enzyme(21) | Tyrosine kinase | 21 | |
Receptor(17) | Transmembrane receptor | 12 | |
| Â | G-protein coupled receptor | 5 | |
Transporter (1) | Transporter | 1 | |
Other (1) | Other | 1 | |