Fig. 3

Statistical analysis the relationship between TFs and candidate modulators. Global analysis of TFs and candidate modulators based on the statistical model. a. The results of influenced targets percent of 82 TFs via the modulation of 165 differential splicing events. In the heatmap, each row represents a TF and each column indicates a splicing event, the color much darker means a much higher percent targets of TF. b. The bipartite network demonstrates the interactions between TFs and candidate modulators which influenced targets percent is more than 30%. Each circle with green color indicates a differential splicing event (modulator), each triangle with blue color represents a TF, the edge between TF and modulator means a physical interaction. c. The heatmap shows the percentage of targets of TFs that are influenced by the splicing patterns of modulators. All the TFs and modulators in c should have protein-protein interaction relationships. Each row represents a TF and each column indicates a splicing event. d. This network shows the predicted interaction between TFs and modulators which targets percent more the 10%. The red wider indicate target percent over 25%, and all these TFs and modulators here have physically interaction evidence