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Table 2 Disease and Bio Functions analysis of influenced targets

From: Roles of alternative splicing in modulating transcriptional regulation

Up-regulated targets

Down-regulated targets

Molecular and Cellular Functions

 Cell Death and Survival

25

Cell Morphology

15

 Cell Morphology

7

Molecular Transport

8

 Cellular Development

8

Protein Synthesis

3

 Cellular Growth and Proliferation

7

Protein Trafficking

2

 Post-Translational Modification

16

Cell-To-Cell Signaling and Interaction

7

Diseases and Disorders

 Infectious Disease

6

Developmental Disorder

11

 Cancer

101

Hereditary Disorder

21

 Organismal Injury and Abnormalities

103

Metabolic Disease

13

 Tumor Morphology

3

Organismal Injury and Abnormalities

65

 Connective Tissue Disorders

10

Renal and Urological Disease

10

  1. IPA analysis results for GR influenced targets when MDM2 as modulator, the list of top 10 terms of function enrichment and related diseases. (p-value <0.01)