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Fig. 1 | BMC Systems Biology

Fig. 1

From: Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma

Fig. 1

The connection between prognosis, genomic variation, and transcriptional MYCN-association in HR-NB. a Significant overlap (p = 0.02, OR = 1.5) exists between the 197 genes harboring verified variants at exon and the 4425 MYCN-associated genes. The latter includes those highly expressed in MYCN-amplified patients or in patients with the normal MYCN copy numbers. b The pathways that are enriched among genes with verified variants at exon over-represent the pathways that are enriched among genes highly expressed in patients with MN HR-NB (OR = 20, P = 7e-3), but are depleted for the pathways that are enriched among genes highly expressed in patients with MA HR-NB (OR = 0.16, P = 0.048). c Kaplan–Meier plots of two identified prognostic GSPs in four independent training cohorts. d Kaplan–Meier analysis of the two GSPs in an independent cohort for event free survival (EFS) and overall survival (OS). In panels c-d, the red lines represent patients with positive indicators (ie, the median expression of the identified genes in red is higher than that of the genes in blue), and the black lines represent patients with negative indicators

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