Fig. 1

Hematopoiesis model overview. Each state of the model is represented with a circle. Mature cells are colored and immature cells are shown with black backgrounds. The compartments of the model are labeled on the top of the figure and indicated with solid colored rectangles. The peripheral blood is divided into two compartments: circulating blood and non-circulating blood, or the marginal pool. Solid arrows represent the differentiation from one state to the state to which the arrow points. A curved arrow indicates self-renewal capability. The group of cells that move are boxed by a gray rounded rectangle. An ‘x’ on the bottom right of a state node represents natural death. The cells that are affected by chemotherapy are encapsulated by the blue rounded rectangular shape. Cells that are undergoing apoptosis and will be cleared by macrophages are in the ‘Apoptosis’ compartment