Fig. 6

Uni-lineage and multi-lineage simulations comparison. The effects of constraining the uni-lineage parameter space for multi-lineage simulations are shown in (a) stem cells, (b) neutrophils in the peripheral blood, (c) lymphocytes in the peripheral blood, and (d) monocytes in the peripheral blood. The distribution of solution concentrations of these cells at three different time points, indicated by red lines in (a-d), of both multi-lineage and uni-lineage are shown for the same respective states in (e-h). The time points were chosen to demonstrate the distributions as cell concentrations are recovering from chemotherapy, at the peak of recovery, and homeostasis post-chemotherapy. The uni-lineage acceptable simulations are shown in green and the multi-lineage acceptable simulations are shown in blue in the front of the image. For the distributions of the simulations, the dotted lines are a dark shade of blue or green and represent the earliest time point, the dashed lines represent a time point around the peak of response, and the solid brightest line represents a steady-state time point. The uni-lineage simulations of stem cells are from the lymphocyte uni-lineage. The distributions were scaled such that the area under each curve is 1