Fig. 8

Survival in leukopoiesis. Each of the thirteen clusters is represented with a distinct color in a-d, corresponding to the same colors as in Fig. 7. (a) Progenitor cancer stem cells (Mc2) grow over one year in each of the 22,796 simulations. The gray lines represents the cell concentration and time in which patients may die due to overgrowth of cancer cells. (b) The percentage of cells in the peripheral blood due to AML in each of the 22,796 simulations. Patients die prior to reaching 100% peripheral blasts, as indicated by gray lines where simulation continued. In (a) and (b), some cluster simulations are not visible because they are underneath the other simulations. (c) The simulated survival curves of each of the thirteen representative clusters of patients are shown assuming the patient dies when either cancer in the bone marrow or the peripheral blood reaches a concentration greater than 3×10⁵ cells/ μL. The cumulative survival is shown as a decimal that represents the fraction of patients that are still alive at the time shown on the x-axis.(d) The distribution of the time to death for each cluster is indicated using box plots. Medians of the distribution are shown as red horizontal bars and outliers are shown as red plus signs (+). (e) Significant cancer parameter correlation to number of days until death due to bone marrow or peripheral blood density greater than 3×10⁵ (p<0.05). (f) Significant cancer parameter correlation constrained with a fixed cancer mitosis rate to the number of days until death due to bone marrow density or peripheral blood density greater than 3×10⁵ (p<0.05). In figures (e) and (f), gray boxes represent insignificant correlations, and the correlation values for each of the thirteen clusters are depicted with the color bar