Table 1 Capabilities of multi-lineage hematopoiesis model
From: An Integrative multi-lineage model of variation in leukopoiesis and acute myelogenous leukemia
Healthy dynamical acceptability criteria |
|---|
1. Peripheral blood recovers > 80 cells/ μL [58] |
2. Stem cells recover > 1 cell/ μL [58] |
3. Final dynamic values are within acceptable ranges (Additional file 1: Supplement 4) [40, 59] |
4. Marginal pool is within one order of magnitude of peripheral blood [43] |
5. Cell counts reduce with chemotherapy to < 20% of original value [63] |
6. Recovery overshoot < 12 times value five days after overshoot [hematopoietic stem cell transplant patient data from Dr. Robert Nelson, shown in Additional file 1: Supplement 5]. |
7. Amplitude of the second peak of oscillations deviates < 18% from the amplitude of the first peak [cutoff calculated, explained in Additional file 5: Supplement 5]. |