Parameter | Lower bound | Upper bound |
|---|
d
Mc
| 0.0001d
M
|
d
M
|
a
M
c2
| 0.01a
M2
| 1 |
m
r
M
c2
| 0.5m
r
M2
| 30 |
m
b
Mc
| 0.0001m
b
M
|
m
b
M
|
- Four parameters were varied for determining the most correlated cancer parameter to survival time: the death rate of cancer (d
Mc
), the self-renewal probability of cancer progenitor cells (a
M
c2), the mitosis rate of cancer progenitor cells (m
r
M
c2), and the mobilization rate of cancer stem cells (m
b
Mc
). The bounds of these parameters were restricted based on the corresponding parameters of monocytes
